13,411 research outputs found

    SO_0(1,d+1) Racah coefficients: Type I representations

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    We use AdS/CFT inspired methods to study the Racah coefficients for type I representations of the Lorentz group SO_0(1,d+1) with d>1. For such representations (a multiple of) the Racah coefficient can be represented as an integral of a product of 6 bulk-to-bulk propagators over 4 copies of the hyperbolic space H_{d+1}. To compute the integrals we represent the bulk-to-bulk propagators in terms of bulk-to-boundary ones. The bulk integrals can be computed explicitly, and the boundary integrations are carried out by introducing Feynman parameters. The final result is an integral representation of the Racah coefficient given by 4 Barnes-Mellin type integrals.Comment: 20 pages, 1 figure. v2: Case d=1 corrected, case d>1 clarifie

    Communication Infrastructures for Distributed Control of Power Distribution Networks

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    In an in vitro model of human tuberculosis, monocyte-microglial networks regulate matrix metalloproteinase-1 and -3 gene expression and secretion via a p38 mitogen activated protein kinase-dependent pathway.

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    BACKGROUND: Tuberculosis (TB) of the central nervous system (CNS) is characterized by extensive tissue inflammation, driven by molecules that cleave extracellular matrix such as matrix metalloproteinase (MMP)-1 and MMP-3. However, relatively little is known about the regulation of these MMPs in the CNS. METHODS: Using a cellular model of CNS TB, we stimulated a human microglial cell line (CHME3) with conditioned medium from Mycobacterium tuberculosis-infected primary human monocytes (CoMTb). MMP-1 and MMP-3 secretion was detected using ELISAs confirmed with casein zymography or western blotting. Key results of a phospho-array profile that detects a wide range of kinase activity were confirmed with phospho-Western blotting. Chemical inhibition (SB203580) of microglial cells allowed investigation of expression and secretion of MMP-1 and MMP-3. Finally we used promoter reporter assays employing full length and MMP-3 promoter deletion constructs. Student's t-test was used for comparison of continuous variables and multiple intervention experiments were compared by one-way ANOVA with Tukey's correction for multiple pairwise comparisons. RESULTS: CoMTb up-regulated microglial MMP-1 and MMP-3 secretion in a dose- and time-dependent manner. The phospho-array profiling showed that the major increase in kinase activity due to CoMTb stimulation was in p38 mitogen activated protein kinase (MAPK), principally the α and γ subunits. p38 phosphorylation was detected at 15 minutes, with a second peak of activity at 120 minutes. High basal extracellular signal-regulated kinase activity was further increased by CoMTb. Secretion and expression of MMP-1 and MMP-3 were both p38 dependent. CoMTb stimulation of full length and MMP-3 promoter deletion constructs demonstrated up-regulation of activity in the wild type but a suppression site between -2183 and -1612 bp. CONCLUSIONS: Monocyte-microglial network-dependent MMP-1 and MMP-3 gene expression and secretion are dependent upon p38 MAPK in tuberculosis. p38 is therefore a potential target for adjuvant therapy in CNS TB

    The Impact of Student Race in the Determination of Eligibility of Emotional Disturbance as Recommended by School Psychologists: Implications for the Disproportionate Representation of African-American Males in Special Education

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    This mixed-method study investigated the impact of student race in the determination of eligibility of emotional disturbance as recommended by school psychologists. The results of this study looked at the implications that the evaluation component of the referral to the Committee on Special Education (CSE) has on the disproportionate representation of African-American males classified with an emotional disturbance. The quantitative component was completed during an experiment involving school psychologists who reviewed student profiles of an African-American male student and a White male student with the same profile. The analysis looked to determine the frequency that the African-American student was classified with an emotional disturbance compared to the White student. The written responses from the school psychologists were analyzed using qualitative data analysis. This analysis looked to determine the rationale school psychologists used in determining eligibility for the classification of emotional disturbance. The data was also analyzed to determine if there was a difference in the rationales provided by the school psychologists based on the race of the student

    Descent of Equivalences and Character Bijections

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    Categorical equivalences between block algebras of finite groups—such as Morita and derived equivalences—are well known to induce character bijections which commute with the Galois groups of field extensions. This is the motivation for attempting to realise known Morita and derived equivalences over non-splitting fields. This article presents various results on the theme of descent to appropriate subfields and subrings. We start with the observation that perfect isometries induced by a virtual Morita equivalence induce isomorphisms of centres in non-split situations and explain connections with Navarro’s generalisation of the Alperin–McKay conjecture. We show that Rouquier’s splendid Rickard complex for blocks with cyclic defect groups descends to the non-split case. We also prove a descent theorem for Morita equivalences with endopermutation source

    Simulation of the quantum dynamics of indistinguishable bosons with the method of coupled coherent states

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    Computer simulations of many-body quantum dynamics of indistinguishable particles is a challenging task for computational physics. In this paper we demonstrate that the method of coupled coherent states (CCS) developed previously for multidimensional quantum dynamics of distinguishable particles can be used to study indistinguishable bosons in the second-quantization formalism. To prove its validity, the technique termed here coupled coherent states for indistinguishable bosons (CCSB) is tested on two model problems. The first is a system-bath problem consisting of a tunneling mode coupled to a harmonic bath, previously studied by CCS and other methods in distinguishable representation in 20 dimensions. The harmonic bath is comprised of identical oscillators, and may be second quantized for use with CCSB, so that this problem may be thought of as a bosonic bath with an impurity. The cross-correlation function for the dynamics of the system and Fourier transform spectrum compare extremely well with a benchmark calculation, which none of the prior methods of studying the problem achieved. The second model problem involves 100 bosons in a shifted harmonic trap. Breathing oscillations in the one-body density are calculated and shown to compare favorably to a multiconfigurational time-dependent Hartree for bosons calculation, demonstrating the applicability of the method as a new formally exact way to study the quantum dynamics of Bose-Einstein condensates

    Energetic consequences of time-activity budgets for a breeding seabird

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    How animals allocate their time to different behaviours has important consequences for their overall energy budget and reflects how they function in their environment. This potentially affects their ability to successfully reproduce, thereby impacting their fitness. We used accelerometers to record time-activity budgets of 21 incubating and chick-rearing kittiwakes (Rissa tridactyla) on Puffin Island, UK. These budgets were examined on a per day and per foraging trip basis. We applied activity-specific estimates of energy expenditure to the kittiwakes\u27 time-activity budgets in order to identify the costs of variation in their allocation of time to different behaviours. Estimates of daily energy expenditure for incubating kittiwakes averaged 494 ± 20 kJ d-1 while chick-rearing birds averaged 559 ± 11 kJ d-1. Time-activity budgets highlighted that kittiwakes did not spend a large proportion of their time flying during longer foraging trips, or during any given 24-h period. With time spent flying highlighted as the driving factor behind elevated energy budgets, this suggests behavioural compensation resulting in a possible energetic ceiling to their activities. We also identified that kittiwakes were highly variable in the proportion of time they spent either flying or on the water during foraging trips. Such variation meant that using forage trip duration alone to predict energy expenditure gave a mean error of 19% when compared to estimates incorporating the proportion of a foraging trip spent flying. We have therefore highlighted that trip duration alone is not an accurate indicator of energy expenditure

    Defining marine important bird areas: Testing the foraging radius approach

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    International audienceRecent international initiatives have promoted a number of different approaches to identify marine Important Bird and biodiversity Areas (IBAs), which are important areas for foraging, migrating or over-wintering seabirds. The ‘Foraging Radius Approach’ is one of these and uses known foraging range and habitat preferences to predict the size and location of foraging areas around breeding colonies. Here we assess the performance of the Foraging Radius Approach using GPS tracking data from six seabird species with a variety of foraging modes. For each species we compared the population home-range areas of our six study species with the home-range areas defined using the Foraging Radius Approach. We also assessed whether basic information on depth preferences from tracking data could improve these home-range area estimates. Foraging Radius Approach home-range areas based on maximum foraging radii encompassed the entire population home-range of five out of six of our study species but overestimated the size of the population home-range area in every case. The mean maximum foraging radius overestimated the population home-range areas by a factor of 4–14 for five of the six species whilst the mean foraging radius overestimated the population home-range area for half of the species and underestimated for the rest. In the absence of other data, the Foraging Radius Approach appears to provide a reasonable basis for preliminary marine IBA identification. We suggest that using the mean value of all previously reported maximum foraging radii, informed by basic depth preferences provides the most appropriate prediction, balancing the needs of seabirds with efficient use of marine space
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